| Bioactivity | Lactisole is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole inhibits insulin secretion induced by glucose in mouse islets[1][2]. |
| Target | T1R3 |
| Invitro | Lactisole (3-10 mM; 48 h) 在小鼠胰腺 β 细胞 MIN6 中抑制 Acesulfame-K、Sucralose (HY-N0614) 和 Glycyrrhizin (HY-N0184) 诱导的胰岛素分泌 (IC50~4 mM)[1]。Lactisole (5 mM; 48 h) 可减弱由 Sucralos 和 Acesulfame-K 引起的细胞质 Ca2+ 浓度升高 ([Ca2+]c)，而不影响细胞内 cAMP 浓度升高 ([cAMP]c)[1]。 |
| Name | Lactisole |
| CAS | 150436-68-3 |
| Formula | C10H11NaO4 |
| Molar Mass | 218.18 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Lactisole
CAS: 150436-68-3 F: C10H11NaO4 W: 218.18
Lactisole is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing re
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.