| Bioactivity | Lactisole free acid is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole free acid inhibits insulin secretion induced by glucose in mouse islets[1][2]. | ||||||||||||
| Target | T1R3 | ||||||||||||
| Invitro | Lactisole free acid (3-10 mM; 48 h) 在小鼠胰腺 β 细胞 MIN6 中抑制 Acesulfame-K、Sucralose (HY-N0614) 和 Glycyrrhizin (HY-N0184) 诱导的胰岛素分泌 (IC50~4 mM)[1]。Lactisole free acid (5 mM; 48 h) 可减弱由 Sucralos 和 Acesulfame-K 引起的细胞质 Ca2+ 浓度升高 ([Ca2+]c)，而不影响细胞内 cAMP 浓度升高 ([cAMP]c)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Lactisole free acid 相关抗体: | ||||||||||||
| CAS | 13794-15-5 | ||||||||||||
| Formula | C10H12O4 | ||||||||||||
| Molar Mass | 196.20 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Hamano K, et al. Lactisole inhibits the glucose-sensing receptor T1R3 expressed in mouse pancreatic β-cells. J Endocrinol. 2015 Jul;226(1):57-66. [2]. Schweiger K, et al. Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects. Nutrients. 2020 Oct 14;12(10):3133. |
Lactisole free acid
CAS: 13794-15-5 F: C10H12O4 W: 196.20
Lactisole free acid is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-
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