| Bioactivity | LabMol-301 inhibits both NS5 RdRp and NS2B-NS3pro activity (IC50: 0.8 and 7.4 μM, respectively). LabMol-301 has a cytoprotective effect and prevents Zika virus (ZIKV)-induced cell death[1]. |
| Target | NS5 RdRp, NS2B-NS3pro |
| Invitro | LabMol-301 (20 μM) shows 99% inhibition rate of NS5 RdRp activity[1].LabMol-301 (10 μM) inhibits more than 80% of the NS2B-NS3pro protease activity[1].LabMol-301 interacts with ZIKV NS2B-NS3pro at the allosteric site relied on a highly hydrophobic complementarity between the molecule’s surfaces and the protein[1].LabMol-301 is able to protect GSC387 cell from cell death induced by ZIKV (EC50: 6.68 μM)[1]. |
| Name | LabMol-301 |
| CAS | 1360243-08-8 |
| Formula | C18H16N6 |
| Molar Mass | 316.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mottin M, et al. Discovery of New Zika Protease and Polymerase Inhibitors through the Open Science Collaboration Project OpenZika. J Chem Inf Model. 2022 Oct 14. |
LabMol-301
CAS: 1360243-08-8 F: C18H16N6 W: 316.36
LabMol-301 inhibits both NS5 RdRp and NS2B-NS3pro activity (IC50: 0.8 and 7.4 μM, respectively). LabMol-301 has a cytop
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