| Bioactivity | LZ-007 is an agonist for farnesoid X receptor (FXR) with an EC50 of 51 nM measuring by TR-FRET assay, or an EC50 of 76 nM in HepG2 cell. LZ-007 exhibits good pharmacokinetic characheristics in SD rats. LZ-007 ameliorates western diet and CCl4 (HY-Y0298)-induced mice metabolic dysfunction-associated steatohepatitis[1] |
| Target | EC50: FXR (51 nM) |
| CAS | 2920000-23-1 |
| Formula | C27H29F3N2O5 |
| Molar Mass | 518.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wang W, et al., Design, synthesis, and biological evaluation of novel highly potent FXR agonists bearing piperidine scaffold. Eur J Med Chem. 2025 Jan 15;282:117082. |
LZ-007
CAS: 2920000-23-1 F: C27H29F3N2O5 W: 518.52
LZ-007 is an agonist for farnesoid X receptor (FXR) with an EC50 of 51 nM measuring by TR-FRET assay, or an EC50 of 76 n
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