LYN-1604 dihydrochloride_product_DataBase

Bioactivity	LYN-1604 dihydrochloride is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC)[1].
Invitro	LYN-1604 is a potential ULK1 agonist (enzymatic activity=195.7% at 100 nM and IC50=1.66 μM against MDA-MB-231 cells) [1]. LYN-1604 binds to wild-type ULK1 with a binding affinity in the nanomole range (KD=291.4 nM) [1].LYN-1604 (0.5, 1.0 and 2.0 μM) induces cell death via the ULK complex in MDA-MB-231 cells[1].LYN-1604 (0.5-2 μM, 24 hours) induces remarkable up-regulation of Beclin-1 and degradation of p62, as well as transformation of LC3-I to LC3-II in MDA-MB-231 cells[1].LYN-1604 induces ATG5-dependent autophagy via the ULK complex[1].LYN-1604 can also increase cleavage of caspase3 and induce apoptosis[1]. Cell Viability Assay[1] Cell Line:
Name	LYN-1604 dihydrochloride
CAS	2310109-38-5
Formula	C33H45Cl4N3O2
Molar Mass	657.54
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

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