| Bioactivity | LY53857 is a potent antagonist of vasoconstriction and serotonin-mediated 5-HT2 receptors. LY53857 did not reduce mean arterial blood pressure in spontaneously hypertensive rats (SHR) at doses that blocked the depressor response to serotonin and blocked central serotonin receptors. In addition, LY53857 was able to enhance neurotransmitter release in rat vas deferens and guinea pig ileal nerves[1]. |
| CAS | 60634-51-7 |
| Formula | C27H36N2O7 |
| Molar Mass | 500.58 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Cohen M L, et al. LY53857, a selective and potent serotonergic (5-HT2) receptor antagonist, does not lower blood pressure in the spontaneously hypertensive rat[J]. Journal of Pharmacology and Experimental Therapeutics, 1983, 227(2): 327-332. [2]. Cohen M L, et al. Receptor specificity of the 5HT2 receptor antagonist, LY53857[J]. Drug development research, 1985, 5(4): 313-321. |