| Bioactivity | LY3154207 is a potent, subtype selective, and orally available human dopamine D1 receptorpositive allosteric modulator (PAM) with minimal allosteric agonist activity (EC50=3 nM)[1]. | ||||||||||||
| Target | EC50: 3 nM (human dopamine D1 receptor) | ||||||||||||
| Invitro | In HEK293 cells transiently expressing human, dog, rhesus monkey, and mouse D1 receptors, the EC50s of LY3154207 are 2.3 nM, 2.0 nM, 2.5 nM, and 62.1 nM, respectively[1]. | ||||||||||||
| Name | LY3154207 | ||||||||||||
| CAS | 1638667-79-4 | ||||||||||||
| Formula | C24H29Cl2NO3 | ||||||||||||
| Molar Mass | 450.40 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Hao J, Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Po |
LY3154207
CAS: 1638667-79-4 F: C24H29Cl2NO3 W: 450.40
LY3154207 is a potent, subtype selective, and orally available human dopamine D1 receptorpositive allosteric modulator (
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.