| Bioactivity | LY3130481 is an AMPA receptor antagonist that is dependent upon transmembrane AMPA receptor regulatory protein (TARP) γ-8, selective inhibits AMPA/TARP γ-8 with an IC50 of 65 nM[1]. | ||||||||||||
| Target | IC50：65 nM (AMPA/TARP γ-8) | ||||||||||||
| Name | LY3130481 | ||||||||||||
| CAS | 1610802-47-5 | ||||||||||||
| Formula | C19H18N4O3S | ||||||||||||
| Molar Mass | 382.44 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Gardinier KM,et al. Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8. J Med Chem. 2016 May 26;59(10):4753-68. |
LY3130481
CAS: 1610802-47-5 F: C19H18N4O3S W: 382.44
LY3130481 is an AMPA receptor antagonist that is dependent upon transmembrane AMPA receptor regulatory protein (TARP) γ
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