| Bioactivity | LY2979165 is the alanine prodrug of 2812223, a selective and potent orthosteric mGlu2 receptor agonist[1]. |
| In Vivo | LY2979165 attenuated the ketamine-evoked BOLD phMRI signal in vivo[2]. |
| Name | LY2979165 |
| CAS | 1311385-32-6 |
| Formula | C13H22N6O6S |
| Molar Mass | 390.42 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Juliet McColm , et al. Evaluation of Single and Multiple Doses of a Novel mGlu2 Agonist, a Potential Antipsychotic Therapy, in Healthy Subjects. Br J Clin Pharmacol. 2017 Aug;83(8):1654-1667. [2]. Mitul A Mehta, et al. Group II metabotropic glutamate receptor agonist prodrugs LY2979165 and LY2140023 attenuate the functional imaging response to ketamine in healthy subjects. Psychopharmacology (Berl). 2018 Jul;235(7):1875-1886. |