| Bioactivity | LY231617 is a potent and blood-brain barrier penetrable antioxidant. LY231617 is a neuroprotective agent in brain, it can be used for the research of nervous disease[1][2]. |
| Invitro | LY231617 (0.25, 1, 5, 10, and 25 μM; overnight) attenuates H2O2 toxicity to hippocampal cultures and shows the best effect at a concertration of 10 μM[1].LY231617 (5 μM; overnight) attenuates 8-isoprostane production and glutathione depletion[1]. |
| In Vivo | LY231617 (50 mg/kg; p.o. 30 minutes before occlusion) reduces global ischemic neuronal injury in rats[2].LY231617 (20 mg/kg; i.v. 30 minutes after occlusion) protects hippocampus and striatum from four-vessel occlusion[2]. Animal Model: |
| Name | LY231617 |
| CAS | 141545-89-3 |
| Formula | C17H30ClNO |
| Molar Mass | 299.88 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Fuson KS, et al. Characterization of LY231617 protection against hydrogen peroxide toxicity. J Neurochem. 1999 Mar;72(3):1154-60. [2]. Clemens JA, et al. The antioxidant LY231617 reduces global ischemic neuronal injury in rats. Stroke. 1993 May;24(5):716-22; discussion 722-3. |