| Bioactivity | LY 295427 is a LDL receptor modulator and a hypocholesterolemic agent. LY 295427 derepresses the transcription of the LDLR (LDL Receptor). LY 295427 can be used for hypercholesterolemia research[1][2][3]. |
| Invitro | LY 295427 时间依赖性地增加中国仓鼠卵巢 (CHO) 细胞对 25-OH chol 的摄取[1]。LY 295427 (2.9 μM) 提高 30% LDL 受体启动子的活性[2]。 |
| In Vivo | LY 295427 剂量依赖性地降低胆固醇-椰子油喂养的仓鼠 LDL-R 转录水平，ED50 值为 40 mg/kg/day[3]。 |
| Name | LY 295427 |
| CAS | 152755-31-2 |
| Formula | C30H52O |
| Molar Mass | 428.73 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bowling N, et al. LY295427, a novel hypocholesterolemic agent, enhances [3H]25-hydroxycholesterol binding to liver cytosolic proteins. J Lipid Res. 1996 Dec;37(12):2586-98. [2]. George Chang, et al. Low density lipoprotein receptor up-regulation. Expert Opinion on Therapeutic Patents. Volume 9, 1999-Issue 5. [3]. Bensch WR, et al. Effects of LY295427, a low-density lipoprotein (LDL) receptor up-regulator, on LDL receptor gene transcription and cholesterol metabolism in normal and hypercholesterolemic hamsters. J Pharmacol Exp Ther. 1999 Apr;289(1):85-92. |