| Bioactivity | LW-216 is a TrxR1 inhibitor that induces Apoptosis. LW-216 has anti-tumor activity[1]. |
| Invitro | LW-216 (5-25 μM, 24 h) 在 NCI-H460 和 A549 细胞中选择性下调 TrxR1 蛋白水平诱导细胞凋亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> LW-216 相关抗体: Western Blot Analysis[1] Cell Line: |
| In Vivo | LW-216 (8 mg/kg, 静脉注射, 两天一次, 持续 18 天) 可抑制异种移植小鼠模型 NCI-H460 细胞的肿瘤生长[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 2146090-18-6 |
| Formula | C30H31NO5 |
| Molar Mass | 485.57 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wang R, et al. Inducing ubiquitination and degradation of TrxR1 protein by LW-216 promotes apoptosis in non-small cell lung cancer via triggering ROS production. Neoplasia. 2024 Jul;53:101004 |