| Bioactivity | LSD1-IN-36 is a potent LSD1 inhibitor with an IC50 value of 0.8 nM. LSD1-IN-36 induces apoptosis and arrests the cell cycle. LSD1-IN-36 shows antitumor activity[1]. |
| Invitro | LSD1-IN-36 (compound 10e) 在几种人类肿瘤细胞系中表现出显著的抑制作用。它对 HCT116 细胞、MCF-7、A549 和 MDA-MB-231 表现出很强的活性，IC50 值分别为 0.1 μM、0.1 μM、0.3 μM 和 0.8 μM[1]。 LSD1-IN-36（0.125-0.5 μM；72 小时）在所有给药浓度下均对 HCT116 克隆的形成表现出显著的抑制作用[1]。LSD1-IN-36（0.125-0.5 μM；72 小时）诱导细胞凋亡并阻止细胞周期[1]。LSD1-IN-36（0.125-0.5 μM；72 小时）增加 HCT116 中 H3K9me2、H3K9me1、H3K4me2 和 H3K4me1 的表达[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> LSD1-IN-36 相关抗体: Cell Cycle Analysis[1] Cell Line: |
| In Vivo | LSD1-IN-36（化合物10e；60 mg/kg；IP；每日；持续3周）在体内表现出显著的肿瘤抑制率[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C22H25N3O6S |
| Molar Mass | 459.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wei Ai, et al. Synthesis, optimization and antitumor activity evaluation of sulfonyl benzoyl hydrazide derivatives as novel human LSD1 inhibitors. Bioorg Med Chem Lett. 2024 Oct 9:114:129982. |