| Bioactivity | LRRK2-IN-3 (compoubd 24) is a potent, selective, orally active and brain-penetrant inhibitor LRRK2, with IC50 of 2.6 nM in human PBMCs. LRRK2-IN-3 can be used for the research of Parkinson's disease[1]. |
| Target | IC50: 2.6 nM (hPBMCs LRRK2) |
| Name | LRRK2-IN-3 |
| CAS | 2641054-60-4 |
| Formula | C25H29ClF2N6O2 |
| Molar Mass | 518.99 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Keylor MH, et, al. Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors. J Med Chem. 2022 Jan 13;65(1):838-856. |
LRRK2-IN-3
CAS: 2641054-60-4 F: C25H29ClF2N6O2 W: 518.99
LRRK2-IN-3 (compoubd 24) is a potent, selective, orally active and brain-penetrant inhibitor LRRK2, with IC50 of 2.6 nM
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