| Bioactivity | LRRK2-IN-2 (compoubd 22) is a potent, selective, orally active and brain-penetrant inhibitor LRRK2, with IC50 of <0.6 nM. LRRK2-IN-2 can be used for the research of Parkinson's disease[1]. |
| Target | IC50: <0.6 nM (LRRK2) |
| Name | LRRK2-IN-2 |
| CAS | 2641059-19-8 |
| Formula | C23H23Cl2F3N6O2 |
| Molar Mass | 543.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Keylor MH, et, al. Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors. J Med Chem. 2022 Jan 13;65(1):838-856. |