| Bioactivity | LPPM-8 is a ligand of Med25 and an inhibitor of Med25 protein-protein interactions (PPIs). LPPM-8 engages Med25 through interaction with the H2 face of its Activator Interaction Domain and stabilizes full-length protein in the cellular proteome. LPPM-8 is an orthosteric inhibitor of H2-binding transcriptional activators (such as ATF6a). LPPM-8 can be used for studying Med25 and Mediator complex biology[1]. |
| Invitro | Med25 是 megadalton Mediator complex 的亚化学计量成分，通过蛋白相互作用与两亲性 ETV/PEA3 家族 (细胞迁移、运动)、ATF6a (应激反应) 和 VP16 (病毒感染) 在转录起始过程中桥接介体和转录激活因子[1]。LPPM-8 (10 和 20 μM) 会抑制 VARIO68 细胞中的 Med25 依赖性基因 (MMP-9)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> LPPM-8 相关抗体: |
| Sequence | {(2S,3R)-3-Hydroxy-2-methylundecanoyl}-{d-(Glu-Asp-Leu-Leu-Leu-Leu-Val)} |
| Shortening | {(2S,3R)-3-Hydroxy-2-methylundecanoyl}-{d-(EDLLLLV)} |
| Formula | C50H89N7O14 |
| Molar Mass | 1012.28 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Pattelli ON, et al. A Lipopeptidomimetic of Transcriptional Activation Domains Selectively Disrupts Med25 Protein-Protein Interactions. Angew Chem Int Ed Engl. 2024 Mar 25:e202400781. |