| Bioactivity | LM-021 is a coumarin-chalcone derivative with anti-aggregatory, antioxidant, neuroprotective and anti-inflammatory properties which suppresses nitric oxide (NO), IL-1β, IL-6, TNF-α production, CD68 antigen (CD68) and histocompatibility-2 (MHCII) expression. LM-021 also attenuates the increase of caspase 1 activity, lactate dehydrogenase release and ROS level. LM-021 can be used for neurological research[1]. |
| Invitro | LM-021 (10 μM, 预处理 8 h，炎症反应下 20 h) 可有效降低小鼠 BV-2 小胶质细胞 NO、IL-1β、IL-6、NLRP3、GAL3、IBA1、CD68 和 MHCII 的表达，并可减轻小鼠 BV-2 小胶质细胞形态的转变[1]。LM-021 (10 μM, 8 h) 可降低 SH-SY5Y 细胞的氧化应激和相关的 polyQ 聚集，促进神经突生长[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> LM-021 相关抗体: |
| Formula | C20H17NO4 |
| Molar Mass | 335.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chen IC, et al. Investigating the therapeutic effects of novel compounds targeting inflammatory IL-1β and IL-6 signaling pathways in spinocerebellar ataxia type 3. Eur J Pharmacol. 2024 Mar 15;967:176370. |