| Bioactivity | LLC1 is an amiloride (HY-B0285) derivative with cytotoxicity against breast cancer cells, particularly those resistant to treatment. The IC50 values of LLC1 for MCF7, MCF7 MX-100, MCF7 TS, MCF7 TR-1, and MCF7 TR-5 are 13, 12, 25, 26, and 19 mM, respectively. LLC1 shows potential for research in the field of cancer therapy[1]. |
| Formula | C17H19ClFN7O |
| Molar Mass | 391.83 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hu M, et al. A novel lipophilic amiloride derivative efficiently kills chemoresistant breast cancer cells. Sci Rep. 2024 Aug 31;14(1):20263. |