| Bioactivity | LL-K12-18 is a two-site molecular glue that enhances the protein-protein interaction of the CDK12-DDB1 complex, stabilizing the CDK12-DDB1 complex and promoting the degradation of cyclin K (EC50=0.37 nM). LL-K12-18 exhibits strong gene transcription inhibition and anti-proliferation effects in tumor cells. LL-K12-18 can be used in cancer research[1]. |
| Formula | C25H32Cl2N10O |
| Molar Mass | 559.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zemin Zhang, et al. "Dual-site molecular glues for enhancing protein-protein interactions of the CDK12-DDB1 complex." Nature Communications 15.1 (2024): 6477. |