| Bioactivity | LK-2 is an antagonist for ASIC1a with a Kd of 1.9 μM. LK-2 reduces glutamate-induced ASIC1a current-enhancement with an IC50 of 6.6 μM. LK-2 exhibits neuroprotective efficacy in mouse ischemic stroke model, with improved motor and coordination skills. LK-2 is blood-brain barrier (BBB) penetrable[1]. |
| CAS | 2649762-09-2 |
| Formula | C12H17N2O5P |
| Molar Mass | 300.25 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lai K, et al., Glutamate acts on acid-sensing ion channels to worsen ischaemic brain injury. Nature. 2024 Jul;631(8022):826-834. |