| Bioactivity | LJH685 is a potent, ATP-competitive and selective RSK inhibitor, inhibits RSK1, 2, and 3 biochemical activities with IC50s of 6, 5, 4 nM, respectively[1]. | ||||||||||||
| Invitro | LJH685 (0.01-100 μM; 72 hours) efficiently inhibits the growth of MDA-MB-231 and H358 cells in soft agar with EC50s of 0.73 and 0.79 μM, respectively[1].LJH685 (0.1-10 μM; 4 hours) efficiently reduces phosphorylation of YB1 at submicromolar concentrations and causes nearly complete inhibition at higher concentrations[1]. Cell Proliferation Assay[1] Cell Line: | ||||||||||||
| Name | LJH685 | ||||||||||||
| CAS | 1627710-50-2 | ||||||||||||
| Formula | C22H21F2N3O | ||||||||||||
| Molar Mass | 381.42 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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LJH685
CAS: 1627710-50-2 F: C22H21F2N3O W: 381.42
LJH685is a potent, ATP-competitive and selective RSK inhibitor, inhibits RSK1, 2, and 3 biochemical activities with IC50
Data collection：peptidedb@qq.com
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