| Bioactivity | LJ-4517 is a potent A2AAR antagonist, with a Ki of 18.3 nM. LJ-4517 is potent in displacing the binding of [3H]ZM241385 (HY-19532) at WT A2AAR[1]. |
| Invitro | LJ-4517 (10 μM) induces cAMP accumulation[1]. |
| Name | LJ-4517 |
| Formula | C19H21N5O3S |
| Molar Mass | 399.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shiriaeva A, et al. GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A2A Adenosine Receptor. J Med Chem. 2022 Aug 17. |