| Bioactivity | LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells[1][2]. | ||||||||||||
| Invitro | LIMK1 inhibitor BMS-4 (compound 4) (0.014-10 μM; 24 h) 在体外抑制 LIMK 而不影响 A549 细胞存活或增殖[1]。LIMK1 inhibitor BMS-4 (0.014-1 μM; 2 h) 在 A549 人肺癌细胞中抑制 LIMK 底物 cofilin 的磷酸化[1]。 | ||||||||||||
| Name | LIMK1 inhibitor BMS-4 | ||||||||||||
| CAS | 905298-84-2 | ||||||||||||
| Formula | C23H23N7O2S | ||||||||||||
| Molar Mass | 461.54 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Collins R, et al. Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity. J Med Chem. 2022 Oct 27;65(20):13705-13713. [2]. Ross-Macdonald P, et al. Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors. Mol Cancer Ther. 2008 Nov;7(11):3490-8. |
LIMK1 inhibitor BMS-4
CAS: 905298-84-2 F: C23H23N7O2S W: 461.54
LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylat
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