| Bioactivity | LH2 peptide is a pH-responsive cell-penetrating peptide dimer with the amino acid sequence LHHLCHLLHHLCHLAG. It can increase its uptake in tumor cells under weakly acidic conditions (such as the tumor microenvironment) through the protonation of histidine residues (pKa approximately 6). When conjugated with the anticancer drug Paclitaxel (HY-B0015), the PTX-LH2 conjugate showed superior tumor suppression effects compared to paclitaxel alone in a subcutaneous breast tumor model. The LH2 peptide holds potential as a drug delivery vehicle in cancer research[1]. |
| Sequence | Leu-His-His-Leu-Cys-His-Leu-Leu-His-His-Leu-Cys-His-Leu-Ala-Gly |
| Shortening | LHHLCHLLHHLCHLAG |
| Formula | C83H128N28O17S2 |
| Molar Mass | 1854.21 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kim J Y, et al. Combination of peptides with biological, organic, and inorganic materials for synergistically enhanced diagnostics and therapeutics[J]. Peptide Science, 2022, 114(3): e24233. |