| Bioactivity | LGB321 monohydrochloride is a potent, selective, orally active and ATP competitive inhibitor of all three PIM kinases. LGB321 monohydrochloride inhibits proliferation, mTOR-C1 signaling and phosphorylation of BAD in a number of cell lines derived from diverse hematologic malignancies. LGB321 monohydrochloride can be used for the research of hematologic malignancies[1]. |
| Name | LGB321 monohydrochloride |
| CAS | 1469925-36-7 |
| Formula | C23H23ClF3N5O2 |
| Molar Mass | 493.91 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Garcia PD, et al. Pan-PIM kinase inhibition provides a novel therapy for treating hematologic cancers. Clin Cancer Res. 2014 Apr 1;20(7):1834-45. |
LGB321 monohydrochloride
CAS: 1469925-36-7 F: C23H23ClF3N5O2 W: 493.91
LGB321 monohydrochloride is a potent, selective, orally active and ATP competitive inhibitor of all three PIM kinas
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