| Bioactivity | LDHA-IN-9 (Compound 1g) is an inhibitor for LDH-A with an IC50 of 25 nM. LDHA-IN-9 inhibits the proliferation of DLD-1 cell (GI50 of 27 μM) through apoptosis induction. LDHA-IN-9 exhibits antitumor activity in mouse model without significant toxicity (25 mg/kg)[1]. |
| Target | IC50: LDHA (25 nM) |
| CAS | 862719-04-8 |
| Formula | C17H22BrNO4 |
| Molar Mass | 384.26 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Cheon SY, et al., Synthesis of 1-Hydroxy(and 1-Alkoxy, 1-Acyloxy)-1H-indoles and evaluations of their suppressive activities against tumor growth through inhibiting lactate dehydrogenase A. Eur J Med Chem. 2024 Nov 30;283:117104. |
LDHA-IN-9
CAS: 862719-04-8 F: C17H22BrNO4 W: 384.26
LDHA-IN-9 (Compound 1g) is an inhibitor for LDH-A with an IC50 of 25 nM. LDHA-IN-9 inhibits the proliferation of DLD-1 c
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