| Bioactivity | LDH-IN-2, a salicylic acid derivative, is an inhibitor of glycolate oxidase (GO). LDH-IN-2 decreases oxalate output in hyperoxaluric hepatocytes. LDH-IN-2 can be used for research of primary hyperoxaluria type 1 (PH1)[1]. |
| Invitro | LDH-IN-2L (compound 34) (10 μM; 24 h) 在 Agxt1-/- 小鼠原代肝细胞中抑制草酸产生的抑制率为 89%[1]。 |
| Name | LDH-IN-2 |
| CAS | 893739-96-3 |
| Formula | C11H8O4 |
| Molar Mass | 204.18 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Moya-Garzón MD, et al. Salicylic Acid Derivatives Inhibit Oxalate Production in Mouse Hepatocytes with Primary Hyperoxaluria Type 1. J Med Chem. 2018 Aug 23;61(16):7144-7167. |
LDH-IN-2
CAS: 893739-96-3 F: C11H8O4 W: 204.18
LDH-IN-2, a salicylic acid derivative, is an inhibitor of glycolate oxidase (GO). LDH-IN-2 decreases oxalate output in h
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