| Bioactivity | LDD39 is a PROTAC targeting RET protein, capable of achieving robust and sustained degradation of total RET (tRET) protein in vivo and inhibiting phosphorylated RET (pRET) signaling. LDD39 is formed by conjugating an E3 ligase ligand (HY-170371) and a target protein ligand (HY-170373) through a linker (HY-30105) (E3 ligase ligand＋Linker: HY-170374)[1]. |
| Formula | C55H59F2N11O6 |
| Molar Mass | 1008.12 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Qiao JX, et al. Discovery and Synthesis of Heterobifunctional Degraders of Rearranged during Transfection (RET) Kinase. J Med Chem. 2024 Nov 14;67(21):19736-19754. |