| Bioactivity | LD4172 is a PROTAC degrader for RIP kinase (RIPK1) with DC50 in nanomolare levels. LD4172 induces apoptosis in cell B16F10 with combination of TNF-α. LD4172 exhibits antitumor efficacy in mouse models[1]. (Pink: ligand for target protein (HY-170613); Black: linker (HY-W012241); Blue: ligand for E3 ligase VHL (HY-112078)) |
| CAS | 2782022-40-4 |
| Formula | C61H75F3N10O7S |
| Molar Mass | 1149.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yu X, et al., Development of a RIPK1 degrader to enhance antitumor immunity. Nat Commun. 2024 Dec 16;15(1):10683. |
LD4172
CAS: 2782022-40-4 F: C61H75F3N10O7S W: 1149.37
LD4172 is a PROTAC degrader for RIP kinase (RIPK1) with DC50 in nanomolare levels. LD4172 induces apoptosis in cell B16F
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