| Bioactivity | LC-1-40 is a PROTAC that selectively degrades NUDT1 (DC50=0.97 nM). LC-1-40 selectively inhibits MYCN-induced tumor growth in mouse models. LC-1-40 also induces nucleotide damage and apoptosis in MYCN-associated tumors. LC-1-40 can be used in cancer research[1]. (Red: NUDT1 binder; Blue: CRBN ligand; Black: Linker). |
| Target | DC50: 0.97 nM (NUDT1). |
| Invitro | LC-1-40 (0.1, 1, 10, 50, 100 µM; 0.5, 1, 2, 4, 6 h) 在 SHEP MYCN-ER 细胞中，能有效地以剂量和时间依赖性的方式诱导 NUDT1 降解[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> LC-1-40 相关抗体: Western Blot Analysis[1] Cell Line: |
| In Vivo | LC-1-40 (30 mg/kg; i.p.; once daily for 15 days) 在小鼠体内，选择性抑制 NUDT1 相关性肿瘤的生长[1]。1.19LC-1-40 在雄性 C57BL/6 小鼠中的药代动力学参数[1]。 |
| Formula | C49H48N8O6 |
| Molar Mass | 844.96 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ye M, et al. Therapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability. Nat Commun. 2024 Mar 16;15(1):2377. |