| Bioactivity | LBM22 is a CDC2-like kinase 2 (CLK2) inhibitor with the IC50 of 3.9 nM. LBM22 has antiproliferative activity and inhibits serine/arginine-rich (SR) protein phosphorylation. LBM22 down-regulates the expression of Wnt-related proteins and anti-apoptotic proteins and can be used for study of non-small cell lung cancer[1]. |
| Formula | C28H22F2N6O2 |
| Molar Mass | 512.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hu T, et al. Discovery of CLKs inhibitors for the treatment of non-small cell lung cancer. Eur J Med Chem. 2024 Oct 9;280:116952. |