| Bioactivity | LAS-31180 is an inhibitor of phosphodiesterase 3, with positive inotropic and vasodilator properties. |
| Invitro | LAS 31180 shows positive inotropic activities in isolated guinea-pig ventricular strips (EC50 of 1.2 mumol/L) and in isolated guinea-pig working hearts[1]. |
| In Vivo | In conscious chronically instrumented beagle dogs, LAS 31180 administered either by intravenous or oral route, shows a dose-dependent, long-lasting positive inotropic effect with minimal effects on heart rate. In hypertensive beagle dogs LAS 31180 elicits a potent and long-lasting fall in blood pressure[1]. |
| Name | LAS-31180 |
| CAS | 137338-43-3 |
| Formula | C11H12N2O3S |
| Molar Mass | 252.29 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gras J, et al. Pharmacological profile of LAS 31180, a new inotropic/vasodilator quinolone derivative. Arzneimittelforschung. 2000 Nov;50(11):980-6. |