| Bioactivity | LAG-3 cyclic peptide inhibitor 12 (Cyclic peptide 12) is an inhibitor of LAG-3 with an IC50 value of 4.45 μM and a Ki value of 2.66 µM[1]. |
| Target | IC50: 4.45 μM (LAG-3).Ki: 2.66 μM (LAG-3). |
| Sequence | Cys-Val-Pro-Met-Thr-{Phe(3-CN)}-Arg-Ala-Cys (disulfide bridge: Cys1-Cys9) |
| Shortening | CVPMT-{Phe(3-CN)}-RAC (disulfide bridge: Cys1-Cys9) |
| Formula | C44H67N13O11S3 |
| Molar Mass | 1050.28 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Calvo-Barreiro L, et al. Design and Biophysical Characterization of Second-Generation cyclic peptide LAG-3 inhibitors for cancer immunotherapy. Bioorg Med Chem Lett. 2024 Nov 15;113:129979. |
LAG-3 cyclic peptide inhibitor 12
CAS: F: C44H67N13O11S3 W: 1050.28
LAG-3 cyclic peptide inhibitor 12 (Cyclic peptide 12) is an inhibitor of LAG-3 with an IC50 value of 4.45 μM and a Ki v
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