| Bioactivity | L803-mts (Myristoylated L 803) is a selective and substrate-competitive GSK-3 peptide inhibitor (IC50: 40 μM). L803-mts also reduces Aβ deposits and ameliorates cognitive deficits in 5XFAD mice. L803-mts shows antidepressive effect in the forced swimming test[1][2]. |
| Name | L803-mts |
| CAS | 1043881-55-5 |
| Sequence | {Myr}-Gly-Lys-Glu-Ala-Pro-Pro-Ala-Pro-Pro-Gln-{Ser(PO3H)}-Pro-NH2 |
| Shortening | {Myr}-GKEAPPAPPQ-{Ser(PO3H)}-P-NH2 |
| Formula | C66H110N15O20P |
| Molar Mass | 1464.64 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kaidanovich-Beilin O, et al. Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on beta-catenin in mouse hippocampus. Biol Psychiatry. 2004 Apr 15;55(8):781-4. [2]. Avrahami L, et al. Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies. J Biol Chem. 2013 Jan 11;288(2):1295-306. |
L803-mts
CAS: 1043881-55-5 F: C66H110N15O20P W: 1464.64
L803-mts (Myristoylated L 803) is a selective and substrate-competitive GSK-3 peptide inhibitor (IC50: 40 μM). L803-mts
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.