| Bioactivity | L759633 is a potent and selective agonist of cannabinoid receptor (CB2) receptor, with Kis of 6.4 nM and 1043 nM for CB2 and CB1 receptors, respectively. L759633 can inhibit Forskolin-stimulated cAMP production[1][2]. |
| Invitro | L759633 (0.1-1000 nM) inhibits Forskolin-stimulated cyclic AMP production in CB2-transfected cells, with an EC50 of 8.1 nM[1].L759633 inhibits Forskolin-stimulated cyclic AMP production by 48% at the concentration of 10 μM[1]. |
| Name | L759633 |
| CAS | 174627-50-0 |
| Formula | C26H40O2 |
| Molar Mass | 384.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ross RA, et, al. Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630. Br J Pharmacol. 1999 Feb;126(3):665-72. [2]. Dhopeshwarkar A, et, al. Functional Selectivity of CB2 Cannabinoid Receptor Ligands at a Canonical and Noncanonical Pathway. J Pharmacol Exp Ther. 2016 Aug;358(2):342-51. |