| Bioactivity | L-Asparaginase (L-ASNase) is a deamidating enzyme that catalyses the hydrolysis of L-asparagine and L-glutamine, and can be used for the research of acute lymphoblastic leukemia. L-Asparaginase depletes L-asparagine from plasma resulting in inhibition of RNA and DNA synthesis with the subsequent blastic cell apoptosis[1]. | ||||||
| Invitro | L-Asparaginase has a cytotoxic effect on AML blasts and LSC subpopulations[1].L-Asparaginase is effective on both CD34+CD38+ and CD34+CD38+ LSC fractions, MSC and monocytes/macrophages partially counteracted the effect[1]. | ||||||
| Name | L-Asparaginase | ||||||
| CAS | 9015-68-3 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |