| Bioactivity | L-AP3, metabotropic glutamate receptor (mGluR) antagonist, inhibits D-phosphoserine and L-phosphoserine with IC50s of 368 μM and 2087 μM, respectively[1]. |
| Invitro | L-AP3 inhibits D-phosphoserine and L-phosphoserine with Kis of 151 μM and 845 μM, respectively[1].L-AP3 has agonistic activity in enhancing phospholipase D activity and decreasing CAMP formation in rat hippocampus[1]. L-AP3 may have selectivity for Group II subtypes since it inhibits [3H]glutamate binding to mGlu3, receptors (Ki 125 μM)[1].L-AP3 is a potent inhibitor of sodium-dependent L-[3H]glutamate uptake in cerebellar and cortical synaptosomes (39 and 110 μM, respectively)[1]. |
| In Vivo | L-AP3 has anticonvulsant activity in animals. L-AP3 blocks audiogenic seizures in DBA/2 mice[1]. |
| Name | L-AP3 |
| CAS | 23052-80-4 |
| Formula | C3H8NO5P |
| Molar Mass | 169.07 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. J E Hawkinson, et al. The metabotropic glutamate receptor antagonist L-2-amino-3-phosphonopropionic acid inhibits phosphoserine phosphatase. Eur J Pharmacol. 1996 Jun 27;307(2):219-25. |