| Bioactivity | L 743310 is a non-peptide, selective antagonist of the human neurokinin hNK1 receptor, with high affinity for primate and cloned human hNK1 receptors and lower affinity for rodent NK1 receptors. L 743310 inhibits resiniferatoxin-induced plasma protein extravasation in guinea pig esophagus. L 743310 has a dose-dependent inhibitory effect on cisplatin-induced emesis[1]. |
| Target | hNK1 receptor |
| CAS | 187724-86-3 |
| Formula | C30H33BrF6N4O2 |
| Molar Mass | 675.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tachykinin NK1 Receptor Antagonists Act Centrally to Inhibit Ernesis Induced by the Chemotherapeutic Agent Cisplatin in Ferrets |
L 743310
CAS: 187724-86-3 F: C30H33BrF6N4O2 W: 675.50
L 743310 is a non-peptide, selective antagonist of the human neurokinin hNK1 receptor, with high affinity for primate an
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