| Bioactivity | L-701252 is a potent antagonist of glycine site NMDA receptor with an IC50 of 420 nM. L-701252 provides a small degree of neuroprotection in global cerebral ischaemia[1]. | ||||||||||||
| Target | NMDA receptor | ||||||||||||
| In Vivo | L-701252 (50 mg/kg; i.p.) provides a small non-significant protection[1]. Animal Model: | ||||||||||||
| Name | L-701252 | ||||||||||||
| CAS | 151057-13-5 | ||||||||||||
| Formula | C13H10ClNO3 | ||||||||||||
| Molar Mass | 263.68 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Stone TW. Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. Trends Pharmacol Sci. 2000;21(4):149-154. [2]. Widdowson PS, et al. Failure of glycine site NMDA receptor antagonists to protect against L-2-chloropropionic acid-induced neurotoxicity highlights the uniqueness of cerebellar NMDA receptors. Brain Res. 1996;738(2):236-242. |
L-701252
CAS: 151057-13-5 F: C13H10ClNO3 W: 263.68
L-701252 is a potent antagonist of glycine site NMDA receptor with an IC50 of 420 nM. L-701252 provides a small degree o
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