| Bioactivity | L-689502 is a potent inhibitor of HIV-l protease with an IC50 of 1 nM. |
| Target | IC50: 1 nM (HIV-l protease) |
| Invitro | Both L694746 and L-689502 inhibit HIV-l ptotease activity in a concentration-dependent manner. Pepstatin is much less potent than either compound exhibiting an IC50 of 2 μM. L694746 is as potent as L-689502 in inhibiting the HIV-l protease despite being structurally different from L-689502[1]. |
| Name | L-689502 |
| CAS | 138483-63-3 |
| Formula | C39H51N3O7 |
| Molar Mass | 673.84 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lingham RB, et al. HIV-1 protease inhibitory activity of L-694,746, a novel metabolite of L-689,502. Biochem Biophys Res Commun. 1991 Dec 31;181(3):1456-61. |