| Bioactivity | L-680833 is a monocyclic β-lactam inhibitor of human polymorphonuclear leukocyte elastase (PMNE) inhibitor. L-680833 can be used for the study of PMNE-damaged tissue diseases[1]. |
| Invitro | L-680833 可抑制由 fMet-Leu-Phe 刺激的分离多形核白细胞释放的酶从纤维蛋白原的 A α 链中产生特定的 N 端裂解产物 A α-(1-21)，IC50 为 0.06 μM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> L-680833 相关抗体: |
| In Vivo | 药代动力学研究表明，口服 L-680833 后，大鼠和恒河猴体内具有生物利用度。这种口服生物利用度体现在：(i) 抑制仓鼠肺因气管内滴注人 PMNE 引起的组织损伤，和 (ii) 抑制人 PMN 转移到小鼠胸腔后刺激其释放的酶[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 127063-08-5 |
| Formula | C27H34N2O5 |
| Molar Mass | 466.57 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. J B Doherty, et al. Chemical, biochemical, pharmacokinetic, and biological properties of L-680,833: a potent, orally active monocyclic beta-lactam inhibitor of human polymorphonuclear leukocyte elastase. Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8727-31. |