L-670596_product_DataBase

Bioactivity	L-670596 is an orally active and selective thrombsxane A2 receptor/prostaglandin receptor antagonist. L-670596 inhibits arachidonic acid (HY-109590) and U-44069 induced bronchoconstriction in the guinea pig. L-670596 also inhibits the aggregation of human platelet rich plasma induced by U-44069[1][2].
Invitro	L-670596 抑制 U-44069 诱导的人类富血小板血浆的聚集[1]。
In Vivo	L-670596 (0.03 mg/kg ; i.v.; single) 抑制豚鼠中花生四烯酸和 U-44069 诱导的支气管收缩[1]。L-670596 (2 mg/kg; i.v.; single) 抑制猪的血小板聚集成胶原蛋白[2]。 Animal Model:
Name	L-670596
CAS	121083-05-4
Formula	C22H21F2NO4S
Molar Mass	433.47
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Ford-Hutchinson AW, et al. The pharmacology of L-670,596, a potent and selective thromboxane/prostaglandin endoperoxide receptor antagonist. Can J Physiol Pharmacol. 1989 Sep;67(9):989-93. [2]. Nuttall GA, et al. Protamine-heparin-induced pulmonary hypertension in pigs: effects of treatment with a thromboxane receptor antagonist on hemodynamics and coagulation. Anesthesiology. 1991 Jan;74(1):138-45.

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