L-4-Oxalysine hydrochloride_product_DataBase

Bioactivity	L-4-Oxalysine hydrochloride is a natural product isolated from the culture media of Streptomyces roseovirdofuscus in China which has shown antitumor activities.
Invitro	Alpha-fetoprotein (AFP) is expressed in BEL-7404 human hepatoma cells and L-4-Oxalysine suppresses AFP mRNA expression in the cells[1]. L-4-oxalysine functionally antagonizes the a-fetoprotein-induced suppression of the mitogen- and one-way mixed lymphocyte culture-induced proliferation of spleen lymphocytes and interleukin-6 production by these cells in mice bearing the hepatoma-22 tumor[2].
In Vivo	Tbe ultrastructural efects of different doses of L-4-Oxalysine on hepatocytes in mice are most serious at day 1 after stopping treatment. Mice are given ig L-4-oxalysine (I-677) 10, 50, and 100 mg/kg for 7 d. On day 8 the hepatocytes show accumulation of lipid droplets followed by loss of matrices in cytoplasm. The total area of lipid droplets is far less than 25% of mean section of hepatocytes. The injury of mitochondria and RER is only found in the groups of medium and high dose[1]. L-4-oxalysine inhibits the proliferation of some mouse implanted tumors and pulmonary metastasis of mouse Lewis lung carcinoma[2].
Name	L-4-Oxalysine hydrochloride
CAS	118021-35-5
Formula	C5H13ClN2O3
Molar Mass	184.62
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reference	[1]. Dai ZQ, et al. Effect of L-4-oxalysine on ultrastructures of liver cells in mice. Zhongguo Yao Li Xue Bao. 1991 Jul;12(4):336-40. [2]. Wang XW, et al. Immunostimulatory action of L-4-oxalysine counteracts immunosuppression induced by alpha-fetoprotein. Eur J Pharmacol. 1998 Jun 12;351(1):105-11.

PeptideDB

L-4-Oxalysine hydrochloride

CAS: 118021-35-5 F: C5H13ClN2O3 W: 184.62