L-156602_product_DataBase

Bioactivity	L-156602 is a C5a receptor antagonist. L-156602 inhibits inflammation, and the migration of monocytes and neutrophils to the infiltrating site in mouse inflammatory models. L-156602 suppresses the efferent phase of delayed-type hypersensitivity (DTH)[1][2].
Target	C5a receptor
In Vivo	L-156602 (0.1-0.5 mg/kg， i.p.，每天一次连续 3 天) 显著抑制 Concanavalin A (HY-P2149) 诱导的 CDF1 小鼠和Muramyl dipeptide (MDP) (HY-127090) 诱导的 BALB/c 小鼠中的炎症[1][2]。L-156602 (0.2-0.5 mg/kg， i.p.) 抑制 PCI 诱导的 DBA/1 小鼠炎症中单核白细胞和中性粒细胞向炎症部位的浸润[2]。 Animal Model:
Name	L-156602
CAS	125228-51-5
Formula	C38H64N8O13
Molar Mass	840.96
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Tsuji RF, et al. Effects of L-156,602, a C5a receptor antagonist, on mouse experimental models of inflammation. Biosci Biotechnol Biochem. 1992 Dec;56(12):2034-6. [2]. Tsuji RF, et al. Anti-inflammatory effects and specificity of L-156,602: comparison of effects on concanavalin A and zymosan-induced footpad edema, and contact sensitivity response. Immunopharmacology. 1995 Feb;29(1):79-87.

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