| Bioactivity | Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits BACE1 (β-site APP cleaving enzyme 1) with an IC50 of 5.45 µM[1][2]. |
| Invitro | Kushenol C dose-dependently suppresses the production of inflammatory mediators, including NO, PGE2, IL-6, IL1β, MCP-1, and IFN-β in LPS-stimulated RAW264.7 macrophages. Kushenol C (50-100 µM;) significantly decreases the phosphorylation of both STAT1 molecules and STAT6 in a dose-dependent manner in LPS-stimulated RAW264.7 cells[1].Kushenol C upregulates the expression of HO-1 and its activities in the LPS-stimulated RAW264.7 macrophages. In HaCaT cells, Kushenol C prevents DNA damage and cell death by upregulating the endogenous antioxidant defense system involving glutathione, superoxide dismutase, and catalase, which prevents reactive oxygen species production from tert-butyl hydroperoxide (tBHP)-induced oxidative stress in HaCaT cells[1]. Kushenol C inhibits BChE and AChE with IC50s of 54.86 and 33.13 µM[2]. |
| Name | Kushenol C |
| CAS | 99119-73-0 |
| Formula | C25H26O7 |
| Molar Mass | 438.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |