| Bioactivity | Kuguaglycoside C is a triterpene glycoside that can be isolated from the leaves of Momordica charantia. Kuguaglycoside C induces caspase‐independent DNA cleavage and cell death of neuroblastoma cells. Kuguaglycoside C also significantly increases the expression and cleavage of apoptosis-inducing factor (AIF)[1]. |
| Invitro | Kuguaglycoside C (0-100 μM, 48 h) 对 IMR-32 细胞具有显着的细胞毒性，IC50 为 12.6 μM[1]。Kuguaglycoside C (30 μM, 48 h) 未显示 caspase-3 或 caspase-9 的激活，但显示 TRADD、AIF 和 DFF45 水平升高，以及 RIP1 和存活蛋白水平降低[1].Hoechst 33342 染色检测显示高浓度 (100 μM) Kuguaglycoside C 诱导细胞核收缩，但流式细胞术未见凋亡小体[1]。 Cell Viability Assay[1] Cell Line: |
| Name | Kuguaglycoside C |
| CAS | 1041631-93-9 |
| Formula | C36H56O8 |
| Molar Mass | 616.83 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tabata K, et al. Kuguaglycoside C, a constituent of Momordica charantia, induces caspase-independent cell death of neuroblastoma cells. Cancer Sci. 2012 Dec;103(12):2153-8. |
Kuguaglycoside C
CAS: 1041631-93-9 F: C36H56O8 W: 616.83
Kuguaglycoside C is a triterpene glycoside that can be isolated from the leaves of Momordica charantia. Kuguaglycoside C
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