Kocurin_product_DataBase

Bioactivity	Kocurin (PM181104) is a thiazolyl cyclic-peptide antibiotic. Kocurin inhibits bacterial growth by impeding bacterial protein biosynthesis during the translation phase. Kocurin has strong inhibitory activity against gram-positive bacteria, but no activity against fungi and Gram-negative bacteria[1].
Invitro	Kocurin (24 小时) 抑制金黄色葡萄球菌，MIC 范围为 0.008 至 2.048 μg/mL，MIC90 值为 0.064 μg/mL[1]。Kocurin (24 小时) 抑制表皮葡萄球菌，MIC 范围为 0.008 至 1.024 μg/mL，MIC90 值为 0.128 μg/mL[1]。Kocurin (24 小时) 抑制 VRE 和 VSE 菌株，MIC 范围为 0.004 至 1.024 μg/mL，MIC90 值为 0.016 μg/mL[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Kocurin 相关抗体:
In Vivo	Kocurin (1.25-10 mg/kg；静脉注射；单剂量) 在 BALB/c 小鼠败血症模型中，对 MRSA 的 100% 有效剂量 (ED100) 值为 2.5 和 5.0 mg/kg，对 VRE 的 ED100 值为 10.0 mg/kg[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	1374772-61-8
Formula	C69H66N18O13S5
Molar Mass	1515.70
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Mahajan G, et al. In vitro and in vivo activities of antibiotic PM181104. Antimicrob Agents Chemother. 2013 Nov;57(11):5315-9.

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