| Bioactivity | Kevetrin hydrochloride is a potent activator of p53, induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells. Kevetrin a preferential cytotoxic activity against blast cells[1][2]. |
| Invitro | Kevetrin hydrochloride (85, 170, 340 µM; 6 h) significantly inhibits KASUMI-1 cells growth in a dose-dependent manner, without affecting MOLM-13 cells[1].Kevetrin hydrochloride (340 µM; 6 h) induces metallothionein (MT) expression in acute myeloid leukemia (AML) cells, and also down-regulates genes in relation to p53 activity, the regulator of WNT/β-catenin signaling forkhead box K2 and the transcription factor signal transducer and activator of transcription 5A (STAT5A)[1].Kevetrin hydrochloride (340 µM; 24 h) induces apoptosis on KASUMI-1 cell line, without leading cell cycle alteration[1].Kevetrin hydrochloride (100, 200, 400 µM; 48 h) increases the mRNA and protein level of p53 and induces p21 protein production in A2780 cells[1]. Cell Viability Assay[1] Cell Line: |
| Name | Kevetrin hydrochloride |
| CAS | 66592-89-0 |
| Formula | C5H10ClN3S |
| Molar Mass | 179.67 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Kevetrin hydrochloride
CAS: 66592-89-0 F: C5H10ClN3S W: 179.67
Kevetrin hydrochloride is a potent activator of p53, induces apoptosis in TP53 wild-type and mutant acute myeloid leukem
Data collection：peptidedb@qq.com
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