| Bioactivity | Ketorolac (RS37619) is a non-steroidal anti-inflammatory drug (NSAID), acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. Ketorolac tromethamine is used as 0.5% ophthalmic solution for the research of allergic conjunctivitis, cystoid macular edema, intraoperative miosis, and postoperative ocular inflammation and pain. Ketorolac tromethamine is also a DDX3 inhibitor that can be used for cancer research[1][4]. |
| Invitro | Ketorolac (RS37619) salt (0-30 μM; 48 h) effectively kills the oral cancer cells[4].Ketorolac salt (0-5 μM; 48 h) inhibits the expression of DDX3 protein, and induces apoptosis in H357 cells[4].Ketorolac salt (0-2.5 μM; 0-16 h) inhibits the proliferation of oral cancer cells[4].Ketorolac salt (0-50 μM) directly interacts with DDX3 and inhibits the ATPase activity[4]. Cell Viability Assay[4] Cell Line: |
| Name | Ketorolac |
| CAS | 74103-06-3 |
| Formula | C15H13NO3 |
| Molar Mass | 255.27 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |