| Bioactivity | Keap1-Nrf2-IN-6 (compound 64) is a potent and selective Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with an IC50 of 41 nM, Kd of 68 nM[1]. |
| Target | IC50: 41 nM (Keap1-Nrf2); Kd: 68 nM |
| Name | Keap1-Nrf2-IN-6 |
| Formula | C30H34N4O8S |
| Molar Mass | 610.68 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Begnini F, et al. Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction. J Med Chem. 2022 Feb 24;65(4):3473-3517. |